Kikkawa lab


Masa Kikkawa’s Publications
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Koshimizu S., Kofuji R., Sasaki-Sekimoto Y., Kikkawa M., Shimojima M., Ohta H., Shigenobu S., Kabeya Y., Hiwatashi Y., Tamada Y., Murata T., Hasebe M.

Physcomitrella MADS-box genes regulate water supply and sperm movement for fertilization
Nature Plants 4, 36-45, 2018. doi: 10.1038/s41477-017-0082-9


●Kuroki K., K. Mio, A. Takahashi, H. Matsubara, Y. Kasai, S. Manaka, M. Kikkawa, D. Hamada, C. Sato, K. Maenaka
Class II-like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer.
J Immunology 2017 Mar 27. pii: 1601296. doi: 10.4049/jimmunol.1601296.


Wang D., R. Nitta, M. Morikawa, H. Yajima, S. Inoue, H. Shigematsu, M. Kikkawa , and N. Hirokawa
Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A.
Elife 2016 Sep 30;5. pii: e18101. doi: 10.7554/eLife.18101.

Yamagishi M., H. Shigematsu, T. Yokoyama, M. Kikkawa, M. Sugawa, M. Aoki, M. Shirouzu, J. Yajima, R. Nitta
Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility.
Structure, 24:1-13, 2016

Oda T., T. Abe, H. A. Yanagisawa, and M. Kikkawa
Docking complex-independent alignment of outer dynein arms with 24-nm periodicity in vitro.
Journal of Cell Science, 1291547-51, 2016

Oda T., T. Abe, H. A. Yanagisawa, and M. Kikkawa
Structure and function of outer dynein arm intermediate and light chain complex
Molecular Biology of the Cell, 27:1051-9, 2016


Oda T., H. A. Yanagisawa, and M. Kikkawa
Detailed Structural and biochemical characterization of the nexin-dynein regulatory complex.
Molecular Biology of the Cell, 26:294-304, 2015


Oda T., H. A. Yanagisawa, R. Kamiya, and M Kikkawa
A molecular ruler determines the repeat length in eukaryotic cilia and flagella
Science, 346:857-860, 2014
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Fujita S., T. Matsuo, M. Ishiura, M. Kikkawa
High-Throughput Phenotyping of Chlamydomonas Swimming Mutants Based on Nanoscale Video Analysis
Biophysical Journal, 107:336-345, 2014

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Yanagisawa HA, G. Mathis, T. Oda, M. Hirono, E. A. Richey, H. Ishikawa, W. F. Marshall, M. Kikkawa, and H. Qin.
FAP20 is an inner junction protein of doublet microtubules essential for both the planar asymmetrical waveform and stability of flagella in
Molecular Biology of the Cell, 25:1472-1483, 2014

(Cover Photo)

Oda T., HA Yanagisawa, T. Yagi, and M. Kikkawa
Mechanosignaling between central apparatus and radial spokes controls axonemal dynein activity
Journal of Cell Biology, 204:807-819, 2014
related EMDB: 5845, 5846, 5847, 5848, 5849, 5850, 5851, 5852, 5853, 5854, 5855

Takarada O., N. Nishida, M. Kikkawa, and I. Shimada
Backbone and side-chain 1H, 15N and 13C resonance assignments of the microtubule-binding domain of yeast cytoplasmic dynein in the high and low-affinity states
Biomolecular NMR Assignments, 8:372-382, 2014


Oda T. and M. Kikkawa
Novel Structural Labeling Method using Cryo-electron Tomography and Biotin-Streptavidin System
Journal of Structural Biology, 183:305-11, 2013
related EMDB: 5711, 5712


Kikkawa M.
Big steps toward understanding dynein
Journal of Cell Biology, 202:15-23, 2013

Oda T., T. Yagi, H. Yanagisawa, and M. Kikkawa
Identification of the Outer-Inner Dynein Linker as a Hub Controller for Axonemal Dynein Activities
Current Biology, 23:656-64, 2013
related EMDB: 5618, 5619, 5620, 5621, 5622

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Bodey A. J., M. Kikkawa and C. A. Moores
9Å structure of a microtubule-bound mitotic motor
Journal of Molecular Biology, 388:218-224, 2009


Kikkawa M.
The role of microtubule in processive kinesin movement.
Trends in Cell Biology, 18:128-135 , 2008


Mizuno N., A. Narita, T. Kon, K. Sutoh, and M. Kikkawa
Three-dimensional structure of cytoplasmic dynein bound to microtubules.
Proc. Natl. Acad. Sci. USA, 104:20832-7, 2007

Narita A., N. Mizuno, M. Kikkawa, and Y. Maeda
Molecular determination by electron microscopy of the dynein-microtubule complex structure.
Journal of Molecular Biology, 372:1320-1336, 2007

Oda T., N. Hirokawa, and M. Kikkawa
Three-dimensional structures of flagellar dynein-microtubule complex by cryo-electron microscopy.
Journal of Cell Biology 177:243-252, 2007

Morfini G., G. Pigino, N. Mizuno, M. Kikkawa, and S. T. Brady
Tau binding to microtubules does not directly affect microtubule-based vesicle motility.
J. Neurosci Research 85:2620-2630, 2007

Metlagel, Z., Y. S. Kikkawa, and M. Kikkawa
Ruby-Helix : An implementation of helical image processing based on object-oriented scripting language
Journal of Structural Biology 157:95-105, 2007


Kikkawa, M. and Z. Metlagel
A molecular "zipper" for microtubules. (preview)
Cell, 127(7):1302-4, 2006

Kikkawa, M. and N. Hirokawa
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations
EMBO Journal, 25:4187-4194, 2006

Arac, D., X. Chen, H. A. Khant, J. Ubach, S. J. Ludtke, M. Kikkawa, A. E. Johnson, W. Chiu, T. C. Südhof, and J. Rizo
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
Nature Structural & Molecular Biology, 13:209-17, 2006


Wu, X., P. B. Alexander, Y. He, M. Kikkawa, P. D. Vogel and S. L. McKnight
Mammalian Sprouty Proteins assemble into large, monodisperse particles having the properties of intracellular Nanobatteries
Proc. Natl. Acad. Sci. U. S. A., 102:14058-62, 2005


Kikkawa, M
A new theory and algorithm for reconstructing helical structures with a seam.
Journal of Molecular Biology, 343:943-955, 2004

Mizuno N., S. Toba, M. Edamatsu, J. Watai-Nishii, N. Hirokawa, Y. Y. Toyoshima and M. Kikkawa
Dynein and kinesin share the same microtubule binding site.
EMBO Journal, 23:2459-2467, 2004

Nitta R., M. Kikkawa, Y. Okada, and N. Hirokawa
Swinging movement of the back door of kinesin generates the alternating use of its two microtubule-binding loops
Science, 305:678-683, 2004


Honma N., Y. Takei, Y. Tanaka, T. Nakata, S. Terada, M. Kikkawa, Y. Noda, and N. Hirokawa
Kinesin Superfamiliy Protein 2A (KIF2A) Functions in Suppression of Collateral Branch Extension
Cell, 114:229-239, 2003


Kikkawa, M., E. P. Sablin, Y. Okada, H. Yajima, RJ Fletterick and N. Hirokawa
Switch Based Mechanism of Kinesin Motors.
Nature, 411:439-445, 2001

Kikkawa, M., Y. Okada, and N. Hirokawa
15Å Resolution Model of the Monomeric Kinesin Motor, KIF1A.
Cell, 100:241-252, 2000

Wolf, S. G., E. Nogales, M. Kikkawa, D. Gratzinger, N. Hirokawa and K. H. Downing
Interpreting a medium-resolution model of tubulin: comparison of Zinc-sheet and microtubule structure.
Journal of Molecular Biology, 262: 485-501, 1996

Kikkawa, M., T. Ishikawa, T. Wakabayashi, and N. Hirokawa
Three-dimensional structure of the kinesin head-microtubule complex.
Nature, 376:274- 276. 1995

Kikkawa, M., I. Ishikawa, T. Nakata, T. Wakabayashi and N. Hirokawa
Direct visualization of the microtubule lattice seam both in vitro and in vivo.
Journal of Cell Biology, 127: 1965-1971, 1994
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